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About CERAZETTE® (desogestrel)

Updated on 15/03/2018

CONTRACEPTION

CERAZETTE is an oestrogen-free pill to primarily inhibit ovulation.1,2,3

CERAZETTE has a 'missed pill window' of 12 hours1 that is comparable to combined oral contraceptives (COCs).4,5

In contrast traditional Progestogen-only pills (POPs) primarily work by thickening the cervical mucus and not inhibition of ovulation. In addition, they have a shorter 'missed pill window' of 3 hours,2 compared with CERAZETTE.1

CERAZETTE therefore offers similar reliability and convenience as COCs1 but greater flexibility of dosing than traditional POPs.2

CERAZETTE also increases the viscosity of the cervical mucus.1

Starting or Switching to CERAZETTE

When can women start using CERAZETTE?

Women can switch from both short-acting and long-acting methods of contraception to CERAZETTE.1 See the table for guidance on when to advise women to start taking CERAZETTE. Please read the Summary of Product Characteristics for more information.1

Changing from Start taking CERAZETTE...
No current hormonal contraception ...on the first day of menstrual bleeding*
Other oral contraceptive (COC) pill ...on the day after the last active COC tablet
Other progestogen-only pill ...on any day without taking a break
Medroxyprogesterone acetate and norethisterone enanthate ...when the next injection would be due
Implant or inatraterine system (IUS) ...on day of implant or IUS removal

*Or days 2-5 with additional barrier method for 1 week.
At latest on the day after the usual pill-free interval with additional barrier method for 1 week.1

Please read the CERAZETTE Summary of Product Characteristics for more information.

Efficacy

Mode of Action and Efficacy

Mode of action In contrast to traditional progestogen-only pills, the contraceptive effect of CERAZETTE is achieved primarily by inhibition of ovulation.1 Other effects include increased viscosity of the cervical mucus.1

Efficacy Similar to combined oral contraceptives, CERAZETTE is
99% effective1

CERAZETTE offers: Ovulation inhibition similar to that of Combined Hormonal Contraceptives (CHCs)2 as well as flexibility with a 'missed pill window' of 12 hours.

DosingCerazette should be taken around the same time each day and has the benefit of 12 hour 'missed pill window'.


Ovulation inhibition Cervical mucus
and/or endometrial
changes
Missed pill window (hours)
CERAZETTE1 12
COCs5,6 12
Other POPs2,3 𝗫 3

Traditional POPs offer no consistent inhibitory effect on ovulation.2,3

References

  1. CERAZETTE Summary of Product Characteristics.
  2. NORIDAY Tablets Summary of Product Characteristics.
  3. Rice, C, Killick S, Dieben T, Coelingh Bennick H. A comparison of the inhibition of ovulation achieved by desogestrel 75 µg and levonorgestrel 30 µg daily. Hum Reprod 1999; 14(4): 982–985.
  4. MICROGYNON 30 Summary of Product Characteristics.
  5. YASMIN film-coated tablets Summary of Product Characteristics.
  6. Milsom I and Korver T. Ovulation incidence with oral contraceptives: a literature review. J Fam Plann Reprod Health Care 2008;34:237-246.

Supporting documentation

Prescribing Information | Summary of Product Characteristics | Patient Information Leaflet

WOMN-1247521-0000 | Date of Preparation: March 2018