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Published on MSD Connect: September 2020

Source: BPS Research Digest

Music and humans go back a very long way. The earliest accepted instruments, made from bones, appeared on the European scene about 40,000 years ago.

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Published on MSD Connect: August 2020

Source: PharmaTimes

NHS England has launched a new drive to put staff wellbeing at the heart of NHS recovery, with measures designed to address new pandemic challenges and improve physical and mental health support for staff.

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Published on MSD Connect: August 2020

Source: PharmaTimes

The Department of Health and Social Care has announced new funding for nursing apprenticeships in England.

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Published on MSD Connect: August 2020

Source: Pa Taz from Press Association

Working conditions for nurses and midwives pose a significant threat to their mental health, which could worsen due to the pandemic, a review has found.

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Published on MSD Connect: August 2020

Source: The Guardian

Doctors may be missing signs of serious and potentially fatal brain disorders triggered by coronavirus, as they emerge in mildly affected or recovering patients, scientists have warned.

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Published on MSD Connect: August 2020

Source: Qatar Tribune

Maintaining a hopeful attitude, developing personal resilience, consciously practising self-care, surrounding oneself with optimistic people, and taking part in activities help relieve stress and encourage social engagement with others, said Dr Javaid Sheikh, professor of Psychiatry and dean of Weill Cornell Medicine-Qatar (WCM-Q).

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Published on MSD Connect: August 2020

Source: The Guardian

People who have recovered from Covid-19 may lose their immunity to the disease within months, according to research suggesting the virus could reinfect people year after year, like common colds.

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Published on MSD Connect: July 2020

Source: The Guardian

Cancer is going undiagnosed for approximately 1,900 people a week due to Covid-19 concerns in hospitals and GP surgeries, with a charity warning the UK now faces a “ticking time bomb".

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Published on MSD Connect: July 2020

Source: The Telegraph

New research finds repetitive negative thinking was linked to the deposit of harmful proteins in the brain. Having constant negative thoughts over a long period of time may increase the risk of developing dementia, scientists believe.

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Published on MSD Connect: July 2020

Source: Medgadget

Manufacturing artificial red blood cells may turn out to be significant in treating a number of diseases and conditions. This has been tried in the past by a number of teams, but some important functions were missing in every design.

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Published on MSD Connect: June 2020

Source: M2 PressWIRE

NHS volunteer responders will be carrying out socially-distanced tasks including helping with delivering food shopping and dropping off personal medication to frontline staff at their homes.

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Published on MSD Connect: May 2020

PharmaTimes

Researchers have created a mobile phone application, dubbed “QUiPP v2”, that allows doctors to quickly calculate a woman's individual risk of preterm birth and identify women who need special treatments.

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Published on MSD Connect: May 2020

Nicola Davis from The Guardian

Hopes of developing a new treatment for ulcerative colitis have been raised by research suggesting the condition may be linked to low levels of certain bacteria in the gut.

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Published on MSD Connect: April 2020

Nicola Davis from The Guardian

An electronic device that “sniffs” breath may offer a new way to identify people with a condition that can lead to cancer of the oesophagus, researchers have revealed.

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Published on MSD Connect: April 2020

Ian Sample Science editor from The Guardian

A powerful antibiotic that kills some of the most dangerous drug-resistant bacteria in the world has been discovered using artificial intelligence.

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Published on MSD Connect: April 2020

Pa Media from The Guardian

A record number of people are at risk of developing type 2 diabetes, increasing their chances of suffering a heart attack or stroke, the NHS has said. A “growing obesity crisis” has led to nearly 2 million people in England being exposed to the condition that causes the level of sugar in the blood to become too high.

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Published on MSD Connect: April 2020

Hannah Devlin from The Guardian

Early signs of cancer can appear years or even decades before diagnosis, according to the most comprehensive investigation to date of the genetic mutations that cause healthy cells to turn malignant.

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Published on MSD Connect: April 2020

Nicola Davis from The Guardian

Human livers from organ donors can now be preserved for a week, researchers have revealed, a dramatic improvement on previous techniques, which could only keep the organs usable for a matter of hours.

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Published on MSD Connect: March 2020

Tony Aern Shaw from Huddersfield Daily Examiner

Advances in artificial intelligence could be the key to identifying people at risk of suicide.

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Published on MSD Connect: March 2020

Agence France-Presse from The Guardian

Smokers can turn back time in their lungs by kicking the habit, with healthy cells emerging to replace some of their tobacco-damaged and cancer-prone ones, a study shows.

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Published on MSD Connect: March 2020

Denis Campbell Health policy editor from The Guardian

People with glaucoma are going blind because NHS eyesight services have “inadequate capacity” to follow up such patients properly after diagnosis, an investigation has revealed.

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Published on MSD Connect: March 2020

Executive Appointments Worldwide

More than 100,000 patients have had appointments with expert pharmacists in the last 10 weeks, relieving pressure on GPs and A&E departments.

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Published on MSD Connect: February 2020

Lauren Donnelly Health Editor from The Telegraph

Cancer helplines are facing a surge in calls from patients because overstretched NHS doctors and nurses do not have time to care for them, a charity has warned.

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Published on MSD Connect: February 2020

Pa Media from The Guardian

Healthy habits such as drinking in moderation, staying slim and exercising for at least 30 minutes a day could extend people’s disease-free life by up to a decade, research suggests.

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Published on MSD Connect: January 2020

Jemma Crew, Pa Health, 6 November 2019

Mental health patients sent away from home for treatment have travelled the equivalent of 22 times around the world in a year.

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Published on MSD Connect: January 2020

Liz Connor, Carmarthen Journal, 20 November 2019

Get into the habit of trying something new each week. It’s a scenario that many of us are familiar with.

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Published on MSD Connect: January 2020

Jamie Harris, Press Association, 11 November 2019

A “smart needle” has been developed by scientists in the UK which could speed up cancer detection and diagnosis times.

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Published on MSD Connect: December 2019

Rebecca Ratcliffe, The Guardian, 15 November 2019

Researchers have discovered a way to stop rabies from shutting down critical responses in the immune system.

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Published on MSD Connect: November 2019

AFP Relax News, 4 November 2019

An at-home, non-invasive screening for cervical pre-cancer could increase compliance with recommended follow-up tests...

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Published on MSD Connect: November 2019

Nina Massey, Press Association, 5 November 2019

A new wearable bike helmet-style brain scanner system could make scans easier and more reliable in children, researchers say.

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Published on MSD Connect: November 2019

Denis Campbell, The Guardian, 15 October 2019

People could be offered cancer screenings in their lunch breaks in a bid to reverse the alarming fall in those attending appointments, under plans being considered by NHS bosses.

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Published on MSD Connect: November 2019

M2 PressWIRE, 21 October 2019

All NHS doctors and dentists in England now have access to a comprehensive mental health service, Health Secretary Matt Hancock has announced today.

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Published on MSD Connect: October 2019

PR Script Managers, Weston, Worle & Somerset Mercurcy, 3 October 2019

GPs across Weston are being encouraged to reduce their reliance on medications and consider prescribing lifestyle changes.

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Published on MSD Connect: October 2019

AFP Relax News, 25 July 2019

According to a British study, women likely to develop diabetes during their pregnancy can reduce the risk by adopting a diet rich in nuts, fruit and olive oil…

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Published on MSD Connect: August 2019

HIT Consultant, 19 June 2019

A lot of discussion about healthcare AI is vague and visionary in nature. Most of us know that these technologies have a very promising future, but until recently it hasn't been clear just when practical applications will emerge.

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Published on MSD Connect: September 2019

Jemma Crew, Pa Health, 15 August 2019

A new NHS initiative will aim to ensure faster diagnosis for people with brain and nerve conditions...

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Published on MSD Connect: September 2019

Harron Siddique, The Guardian, 11 August 2019

Thousands of people in England at risk of contracting type 2 diabetes will receive wearable tech to help monitor their exercise level, the NHS has said.

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Published on MSD Connect: August 2019

Healthline, 3 July 2019

People under 35 years old are ignoring warnings about sun exposure and skin cancer because they believe tanning makes people more attractive.

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Published on MSD Connect: August 2019

PharmaTimes, 6 June 2019

NHS England has announced that nearly three quarters of a million patients are set to benefit from new world-leading innovations on the...

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Published on MSD Connect: December 2019

Simon Neville, Press Association, 7 July 2019

More than a dozen NHS Trusts are taking the Government to court to argue that they should have an 80% reduction in business rates – the same discount given to private hospitals and fee-paying...

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Published on MSD Connect: August 2019

M2 PressWIRE, 1 July 2019

Screening programmes will be overhauled and diagnosis made faster and more accurate with...

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Published on MSD Connect: August 2019

Letters, The Guardian, 16 July 2019

The NHS Confederation report Chairs and Non-Executive Directors in the NHS did not give a fair picture of what is actually going on in the health service today...

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Published on MSD Connect: August 2019

CEO, Innovaccer Inc & Abhinav Shashank, HIT Consultant, 19 June 2019

The world of healthcare is changing and with it our approach to understanding the concept of patients and doctors, ways of delivering care and building a better relationship between those...

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Published on MSD Connect: December 2019

Manas Mishra, Reuters, 28 June 2019

Family background can matter for the health of diabetic children, according to researchers in...

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Published on MSD Connect: August 2019

Fulcoe, Cleveland Clinic, 13 July 2019

If your patients have diabetes, you know how easy it is for them to injure their feet — without even realising...

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Signs of cancer can appear long before diagnosis, study shows

Hannah Devlin from The Guardian

Published on MSD Connect: April 2020

Early signs of cancer can appear years or even decades before diagnosis, according to the most comprehensive investigation to date of the genetic mutations that cause healthy cells to turn malignant. The findings, based on samples from more than 2,500 tumours and 38 cancer types, reveal a longer-than-expected window of opportunity in which patients could potentially be tested and treated at the earliest stages of the disease.

A doctor discusses medical information with a teenage girl, who is wearing a head scarf, and her father.

The work was carried out as part of the Pan-Cancer Analysis of Whole Genomes project, the most comprehensive study of cancer genetics to date.

“What’s extraordinary is how some of the genetic changes appear to have occurred many years before diagnosis, long before any other signs that a cancer may develop, and perhaps even in apparently normal tissue,” said Clemency Jolly, a co-author of the research based at the Francis Crick Institute in London.

“Unlocking these patterns means it should now be possible to develop new diagnostic tests that pick-up signs of cancer much earlier,” said Peter Van Loo, co-lead author, also of the Crick Institute. “There is a window of opportunity.”

The discovery that the seeds of cancer are often sown many years before the first symptoms arise will not change cancer screening in the immediate term. But it points to the possibility that those at risk could be spotted far earlier.

The study revealed that about half of the earliest mutations occurred in just nine genes, meaning there is a relatively small pool of common genes that serve as triggers for cells to diverge from healthy development to a path towards cancer. It might be possible, in future, to pick up such mutations using so-called liquid biopsies – genetic tests that detect mutations in free-floating DNA carried in the blood that can indicate the presence of tumours elsewhere in the body.

“One could try and identify these [early mutations] and do some kind of very sensitive imaging on patients that were positive,” said Van Loo. “Or even further into the future, one could conceive of methods that really targeted these cells and made them light up in an imaging approach or just kill them in one go. That’s a bit science fiction at the moment.”

About 363,000 new cancer cases are reported in the UK every year, according to Cancer Research UK, with the disease causing 165,000 deaths annually.

The team analysed and sequenced nearly 2,700 whole genomes of cancer samples and mapped mutations in 38 different types of tumours.

While human cells undergo billions of mutations, only a small number of them, called driver mutations, give rise to cancer. The researchers looked at how many times a single change, or driver mutation, had been replicated and copied across chromosomes.

Using what they describe as a “carbon-dating method”, they were able to reconstruct the order in which the genomes of cancer cells started to accumulate errors and eventually carry large segments that had been scrambled or copied. The team found that these mutations occurred “particularly early” in ovarian cancer as well as in two types of brain tumour, glioblastoma and medulloblastoma.

The analysis is published in Nature as part of a wider collection of 22 papers from the Pan-Cancer project.

Previous research on cancer genetics has focused on the so-called coding regions of the genome, which contain the instructions for cells to make proteins.

Lincoln Stein, of the Ontario Institute for Cancer Research in Canada, who is also a member of the Pan-Cancer project steering committee, said: “The vast majority of work so far has been on the protein coding portion of the genome. That’s a mere 1%. It’s like trying to put together a 100,000-piece jigsaw puzzle when you’re missing 99% of the pieces and there’s no puzzle box with a completed picture to guide you.”

The latest research provides some of the first detailed insights into the role of the other 99% of our DNA – the genome’s “dark matter” – and how these less-studied regions contribute to cancer. The study identifies several important genes that lie outside the coding region. Stein said these newly identified genes would increase the proportion of patients for whom a cancer-causing mutation could be pinpointed from about two-thirds to 95%.

“Prior to that, we would be in the dark about roughly one-third of patients that came into the clinic,” Stein added.

This article was originally published by The Guardian, 5 February 2020.

This article was written by Hannah Devlin Science correspondent from The Guardian and was legally licensed through the NewsCred publisher network. Please direct all licensing questions tolegal@newscred.com.

Minor grammatical and translational editorial changes may have been made to this article by MSD, which has no impact on the content of the article. This is to ensure all articles remain as relevant as possible to UK Healthcare Professionals.

GB-NON-02275 | Date of Preparation: February 2020