- Nearly all patients achieved adequate intubation conditions within 60 seconds2
- 80% of intubations were rated excellent2
- Rocuronium bromide had a similar train-of-four (TOF) fade and a fast onset of action when compared with equipotent doses of other non-depolarizing NMBAs11
Onset times of NMBAS

*p<0.01 vs mivacurium and vecuronium; **p<0.01 versus atracurium and rocuronium; patients excluded for protocol violations (vecuronium n=2; cisatracurium=1).
Adapted from Carroll et al, 1998 11
90 patients aged 18-65 and classified as grade 1 or 2 according to the American Society of Anesthesiologists Physical Status Classification System were included in the study. Anaesthesia was induced with fentanyl 1 to 5 µg/kg and propofol 1.5 to 2.5 mg/kg followed by 66% nitrous oxide in oxygen and a propofol infusion. The ulnar nerve was stimulated at the wrist with supramaximal stimuli to 0.2 ms duration, in a TOF mode at 2 Hz every 12 seconds. Following stabilisation of control responses, patients were randomly allocated (using a computer generated list) to receive cisatracurium 0.05 (n=14) or 0.1 mg/kg (n=14), atracurium 0.5 mg/kg (n=15), mivacurium 0.15 mg/kg (n=15), vecuronium 0.08 mg/kg (n=13), or rocuronium 0.6 mg/kg (n=15) over 5 seconds into a fast-flowing infusion. TOF fade characteristics and onset of action were recorded.11