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This section of the website is for UK healthcare professionals only. If you are not a healthcare professional, please click here.

ZEPATIER® (elbasvir/grazoprevir)

Power to cure* in People Who Inject Drugs (PWIDs)1

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93% SVR for G1+G4 patients on OST, many of whom continued to take recreational drugs1

Study Primary End Point

The proportion of patients in the ITG achieving an SVR, defined as an HCV RNA level less than the lower limit of quantitation (<15 IU/mL) at 12 weeks after the end of treatment (SVR12)

ZEPATIER 93% SVR image

Approximately 62% of patients in the immediate treatment arm continued to use recreational drugs throughout the trial1

Recreational drug use during C-Edge co-star trial
  • ZEPATIER has no drug-drug interactions with buprenorphine/naloxone and methadone2
  • Concomitant recreational drug use did not affect efficacy of ZEPATIER in patients receiving OST1
  • Patients receiving OST were highly (defined as >95%) adherent to ZEPATIER, due to study protocol, via post-hoc analysis†1
Additional data and C-Edge Co-Star study design

WHO draft global health sector strategy on viral hepatitis, 2016-2021

'A goal of eliminating viral hepatitis as a major public threat by 2030'3

If we are to eliminate hepatitis C as a major public health threat, there are two main impact areas where we need to make progress: we need to reduce the numbers becoming seriously ill or dying from this infection, whilst at the same time reducing the number of people who become newly or re-infected.3


*Cure defined as Cure of HCV infection = Sustained Virologic Response (SVR), the primary endpoint in all studies, was defined as Hepatitis C Virus (HCV) Ribonucleic Acid (RNA) less than the Lower Limit of Quantification (LLOQ) (≤15 IU/ml) at 12 weeks after the cessation of treatment4

**Includes all patients; reinfections counted as failures

C-Edge Co-Star, Full analysis set. 192 out of 199 patients in a post-hoc analysis took >95% of the 84 doses of ZEPATIER administered over 12 weeks1

Related content

 

References

  1. Dore GJ et al. Elbasvir–Grazoprevir to Treat Hepatitis C Virus Infection in Persons Receiving Opioid Agonist Therapy. Ann Intern Med. doi:10.7326/M16-0816.
  2. ZEPATIER Summary of Product Characteristics.
  3. WHO global health sector strategy on viral hepatitis, 2016-2021.
  4. European Association for the Study of Liver. J Hepatol 2018;69;461-511.

Supporting documentation

Prescribing Information (Great Britain) & Prescribing Information (Northern Ireland)
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GB-ZEP-00144 | Date of Preparation: November 2021