About KEYTRUDA in endometrial cancer

KEYTRUDA® (pembrolizumab) in endometrial cancer

Prescribing Information (Great Britain) & Prescribing Information (Northern Ireland) [External links]

KEYTRUDA, in combination with lenvatinib, is indicated for the following:

Advanced or recurrent endometrial carcinoma
For use in
The treatment of advanced or recurrent endometrial carcinoma in adults who have disease progression on or following prior treatment with a platinum-containing therapy in any setting, and who are not candidates for curative surgery or radiation.1
Dosing schedule
The recommended dose is either 200 mg every 3 weeks or 400 mg every 6 weeks, administered as an intravenous infusion over 30 minutes.1
Duration of treatment
Treat until disease progression or unacceptable toxicity.1
Clinical trialKEYNOTE-775 was a multicentre, open-label, Phase 3 trial, for patients with confirmed advanced, recurrent, or metastatic endometrial cancer of any histologic subtype, except carcinosarcoma and sarcoma. Patients were assigned in a 1:1 ratio to receive either lenvatinib plus pembrolizumab, or chemotherapy of the treating physician’s choice (with doxorubicin or paclitaxel chosen before randomisation in the chemotherapy group).2

Click here to download the KEYNOTE-775 clinical data presentation.


Refer to the Summary of Product Characteristics and Risk Minimisation materials available on the emc website before prescribing, in order to help reduce the risk associated with KEYTRUDA.


  1. KEYTRUDA Summary of Product Characteristics.
  2. Makker V et al. N Engl J Med. 2022;386:437–448.

Supporting documentation

Prescribing Information (Great Britain) & Prescribing Information (Northern Ireland) 
By clicking the links above you will leave the MSD Connect website and be taken to the emc PI portal website